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KMID : 0032220190310030315
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Annals of Dermatology
2019 Volume.31 No. 3 p.315 ~ p.319
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Topical Brimonidine as an Effective Adjuvant to Local Anesthetics for Post Treatment Erythema and Pain Reduction
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Kwon Hyun-Jung
Kim Jae-Min
Jeong Guk-Jin
Lee Sang-Ju
Lee Hae-Woong
Park Kui-Young
Seo Seong-Jun
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Abstract
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Background: There are few pharmacologic options to reduce laser-associated post treatment erythema and to extend topical anesthesia duration. To improve the tolerability of painful laser treatment, dermatologists should encourage development of a novel adjuvant agent to topical lidocaine cream.
Objective: To report the efficacy and safety of a combination of topical brimonidine and anesthetic cream as an aid for post treatment erythema and pain.
Methods: A total of 15 Korean subjects were randomized to receive a split-face application of a mixture of brimonidine and anesthetics on one side and only anesthetics on the other side of the face for anesthesia. After non-ablative fractional full-face skin resurfacing, Clinician's Erythema Assessment, erythema index, and visual analogue scale were assessed at four time points: immediately after resurfacing, 30 minutes after, 60 minutes after, and 1 day after.
Results: A combination of brimonidine and anesthetics significantly lowered post treatment erythema until 60 minutes after the laser procedure. Furthermore, patients reported significantly lower post-procedural pain from the side of their face that received the mixture of anesthetics and brimonidine than they did for the side that only received anesthetics.
Conclusion: Topical brimonidine can be used as an effective adjuvant agent to lidocaine-based topical anesthetics.
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KEYWORD
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Alpha-2-agonist, Anesthesia, Brimonidine tartrate, Erythema, Pain
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